2024

原著

  • Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity
    • Ryunosuke Muro, Takeshi Nitta, Sachiko Nitta, Masayuki Tsukasaki, Tatsuo Asano, Kenta Nakano, Tadashi Okamura, Tomoki Nakashima, Kazuo Okamoto, and Hiroshi Takayanagi 
      • J Clin Invest. 134(20):e179612. 2024.
  • Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis.
    • Tatsuyuki Fukui, Asuka Terashima, Yasunori Omata, Ryota Chijimatsu, Kazuo Okamoto, Masayuki Tsukasaki, Yukiko Fukuda, Tadayoshi Hayata, Akiyoshi Saitoh, Etsuko Toda, Hiroshi Takayanagi, Sakae Tanaka, Yuya Terashima, Taku Saito
      • J Bone Miner Metab 2024. doi: 10.1007/s00774-024-01555-x.
  • The periosteum provides a stromal defence against cancer invasion into the bone
    • Kazutaka Nakamura, Masayuki Tsukasaki*(corresponding author), Takaaki Tsunematsu, Minglu Yan, Yutaro Ando, Nam Cong-Nhat Huynh, Kyoko Hashimoto, Qiao Gou, Ryunosuke Muro, Ayumi Itabashi, Takahiro Iguchi, Kazuo Okamoto, Takashi Nakamura, Kenta Nakano, Tadashi Okamura, Tomoya Ueno, Kosei Ito, Naozumi Ishimaru, Kazuto Hoshi, Hiroshi Takayanagi
      • Nature  2024. doi: 10.1038/s41586-024-07822-1.
  • Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis
    • Tokuju Okano, Hiroshi Ashida, Noriko Komatsu, Masayuki Tsukasaki, Tamako Iida, Marie Iwasawa, Yuto Takahashi, Yasuo Takeuchi, Takanori Iwata, Miwa Sasai, Masahiro Yamamoto, Hiroshi Takayanagi, Toshihiko Suzuki
      • International Journal of Oral Science 16(1):54, 2024.
  • Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis
    • Nam Cong-Nhat Huynh, Rui Ling, Masatsugu Komagamine, Tianshu Shi, Masayuki Tsukasaki, Kotaro Matsuda, Kazuo Okamoto, Tatsuo Asano, Ryunosuke Muro, Warunee Pluemsakunthai, George Kollias, Yuko Kaneko, Tsutomu Takeuchi, Sakae Tanaka, Noriko Komatsu, Hiroshi Takayanagi
      • Inflammation and Regeneration 44(1):36. 2024.
  • Synchronized development of thymic eosinophils and thymocytes
    • Ayami Ota, Takahiro Iguchi, Sachiko Nitta, Ryunosuke Muro, Nanami Mino, Masayuki Tsukasaki, Josef M Penninger, Takeshi Nitta, Hiroshi Takayanagi
      • International Immunology 2024. doi: 10.1093/intimm/dxae037.
  • The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
    • Yutaro Ando, Masayuki Tsukasaki*(corresponding author), Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Akira Yamaguchi, Kazuyuki Ishihara, Hiroshi Takayanagi
      • International Journal of Oral Science 16(18) 1-9, 2024.

和文総説

  • 転写因子Ets1 を介した組織破壊型の線維芽細胞誘導機構
    • 塚崎雅之，室龍之介，高柳広
      • 感染・炎症・免疫  54(2) 13-20, 2024. 
  • 臨床と基礎の融合 4 小児歯科研究から見える歯科医学の未来と可能性
    • 福本敏, 高井基普, 塚崎雅之, 吉野晃
      • 歯界展望 143(6) 1038-1059, 2024. 
  • 臨床と基礎の融合 3 矯正歯科臨床と骨細胞の形を突き詰める.
    • 上岡寛, 高井基普, 塚崎雅之, 吉野晃
      • 歯界展望 143(1) 132-158, 2024.

2023

原著

  • Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
    • Minglu Yan, Masayuki Tsukasaki*(corresponding author), Ryunosuke Muro, Yutaro Ando, Kazutaka Nakamura, Noriko Komatsu, Takeshi Nitta, Tadashi Okamura, Kazuo Okamoto, Hiroshi Takayanagi
      • Bone Research 11(1):43. 2023.

和文総説

  • 臨床と基礎の融合2 口腔に存在するウイルスの意義.－ウイルス学視点は歯周治療を変えうるのか？－.
    • 今井健一, 高井基晋, 塚崎雅之, 吉野晃
      • 歯界展望 142(5) 884-912, 2023.
  • RANKLと歯周病
    • 安藤雄太郎, 塚崎雅之
      • 日本薬理学雑誌 158(3) 263-268, 2023. 
  • 歯周病と骨免疫学
    • 安藤雄太郎, 塚崎雅之
      • 歯界展望 141(3) 455-465, 2023.
  • 骨代謝を調節する微細環境- 免疫系
    • 塚崎雅之, 高柳広
      • 日本臨床 増刊号 最新の骨粗鬆症学（第2版） 111-117, 2023.
  • シングルセル解析による骨代謝制御機構の解明
    • 塚崎雅之
      • 日本臨床 増刊号 最新の骨粗鬆症学（第2版） 71-75, 2023.

2022

原著

  • ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts
    • Minglu Yan,Noriko Komatsu, Ryunosuke Muro, Nam Cong-Nhat Huynh, Yoshihiko Tomofuji, Yukinori Okada, Hiroshi I. Suzuki, Hiroyuki Takaba, Riko Kitazawa, Sohei Kitazawa, Warunee Pluemsakunthai, Yuichi Mitsui, Takashi Satoh, Tadashi Okamura, Takeshi Nitta, Sin-Hyeog Im, Chan Johng Kim, George Kollias, Sakae Tanaka, Kazuo Okamoto, Masayuki Tsukasaki, Hiroshi Takayanagi
      • Nature Immunology  23(9):1330-1341, 2022.
  • Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
    • Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron, Hiroshi Takayanagi
      • Nature Communications 13(1) :4166, 2022.
  • Skeletal muscle mitoribosomal defects are linked to low bone mass caused by bone marrow inflammation in male mice
    • Jingwen Tian, Hyo Kyun Chung, Ji Sun Moon, Ha Thi Nga, Ho Yeop Lee, Jung Tae Kim, Joon Young Chang, Seul Gi Kang, Dongryeol Ryu, Xiangguo Che, Je‐Yong Choi, Masayuki Tsukasaki, Takayoshi Sasako, Sang‐Hee Lee, Minho Shong, Hyon‐Seung Yi
      • Journal of Cachexia, Sarcopenia and Muscle  13(3):1785-1799. 2022.

総説

  • Osteoclast biology in the single-cell era
    • Masayuki Tsukasaki, Hiroshi Takayanagi
      • Inflammation and Regeneration 42(1):27, 2022.

和文総説

  • 臨床と基礎の融合 1〜歯周病における基礎と臨床〜
    • 前川知樹, 片桐さやか, 髙井基普, 塚崎雅之, 吉野晃
      • 歯界展望 140(5) 870-898, 2022.
  • シングルセル時代における破骨細胞生物学
    • 塚崎雅之
      • 炎症と免疫 30(6) 490-494, 2022.
  • サウナや水風呂の嗜好性は遺伝子で決まるのか? ~温度感受性遺伝子の日本・フィンランド間ゲノム比較解析~
    • 石田充輝, 塚崎雅之
      • The Japanese Journal of Sauna, vol.2, 2022
  • 口腔細菌叢と骨免疫系の連関
    • 塚崎雅之, 高柳広
      • 糖尿病・内分泌代謝科  54(6):776-785, 2022.
  • 破骨細胞制御機構に関する新知見
    • 塚崎雅之
      • 骨・軟骨・筋科学Update (2):13-15, 2022.

2021

原著

  • Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus
    • Mikhail M. Kostik, Maria A. Makhova, Alexei S. Maletin, Shamai M. Magomedova, Lybov S. Sorokina, Masayuki Tsukasaki, Kazuo Okamoto, Hiroshi Takayanagi, Dmitriy S. Vasiliev, Darya I. Kozlova, Alexander Yu. Mushkin
      • Cytokine 143:155521-155521, 2021.
  • Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis
    • Noriko Komatsu, Stephanie Win, Minglu Yan, Nam Cong-Nhat Huynh, Shinichiro Sawa, Masayuki Tsukasaki, Asuka Terashima, Warunee Pluemsakunthai, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi
      • Journal of Clinical Investigation 131(6):e143060. 2021.

著書

  • 歯学生・歯科医療従事者のための骨免疫学 （医歯薬出版）
    • 塚崎雅之

和文総説

  • 骨構成細胞における温度感受性遺伝子群の発現
    • 塚崎雅之, 石田充輝
      • The Japanese Journal of Sauna, vol.1, 2021.
  • 骨による免疫制御
    • 塚崎雅之
      • 体育の科学 71(10) 729-734, 2021. 
  • インプラント臨床と骨免疫学
    • 塚崎雅之
      • 歯界展望 137(6) 1252-1265, 2021. 
  • 骨免疫学からみた生体防御と歯周病
    • 塚崎雅之
      • 歯界展望 137(4) 762-774, 2021.
  • 生命科学における歯科医学の重要性
    • 塚崎雅之
      • 歯界展望 137(2) 302-318, 2021.

2020

原著

  • Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution
    • Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Kazuo Okamoto, Ryunosuke Muro, Asuka Terashima, Yoshitaka Kurikawa, Noriko Komatsu, Warunee Pluemsakunthai, Takeshi Nitta, Takaya Abe, Hiroshi Kiyonari, Tadashi Okamura, Mashito Sakai, Toshiya Matsukawa, Michihiro Matsumoto, Yasuhiro Kobayashi, Josef M. Penninger, Hiroshi Takayanagi
      • Nature Metabolism 2(12):1382-1390, 2020.
  • OPG Production Matters Where It Happened
    • Masayuki Tsukasaki, Tatsuo Asano, Ryunosuke Muro, Nam Cong-Nhat Huynh, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Takeshi Nitta, Hiroshi Takayanagi
      • Cell Reports  32(10):108124, 2020.

総説

  • RANKL and osteoimmunology in periodontitis
    • Masayuki Tsukasaki
      • Journal of Bone and Mineral Metabolism 39(1):82-90. 2020.

2019

総説

  • Osteoimmunology: evolving concepts in bone-immune interactions in health and disease.
    • Masayuki Tsukasaki, Hiroshi Takayanagi
      • Nature Reviews Immunology  19(10):626-642, 2019.

和文総説

  • 骨免疫学が紐解く歯科臨床の分子基盤
    • 塚崎雅之
      • 歯界展望  134(3):472-508, 2019. 
  • 口腔細菌叢と骨
    • 塚崎雅之
      • BIO Clinica  34(8):17-21, 2019. 

2018

原著

  • Host defense against oral microbiota by bone-damaging T cells
    • Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, Hiroshi Takayanagi
      • NatureCommunications 9(1):701, 2018.

2017

原著

  • LOX Fails to Substitute for RANKL in Osteoclastogenesis
    • Masayuki Tsukasaki, Koki Hamada, Kazuo Okamoto, Kazuki Nagashima, Asuka Terashima, Noriko Komatsu, Stephanie J. Win, Tadashi Okamura, Takeshi Nitta, Hisataka Yasuda, Josef M. Penninger, Hiroshi Takayanagi
      • Journal of Bone and Mineral Research 32(3):434-439, 2017.

2016

原著

  • Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3.
    • Katsuhiro Hiranuma, Atsushi Yamada, Tamaki Kurosawa, Ryo Aizawa, Dai Suzuki, Yoshiro Saito, Ryo Nagahama, Mikiko Ikehata, Masayuki Tsukasaki, Naoko Morimura, Daichi Chikazu, Koutaro Maki, Tatsuo Shirota, Masamichi Takami, Matsuo Yamamoto, Takehiko Iijima, Ryutaro Kamijo
      • FEBS Open Bio 6(9):914-918, 2016.

2014

和文総説

  • RANKL-RANK-OPGシステムによる破骨細胞分化と制御
    • 塚崎雅之, 高柳広
      • O.li.v.e. －骨代謝と生活習慣病の連関－ 4(4) 274-276, 2014

2013

原著

  • BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation
    • Takashi Matsumoto, Atsushi Yamada, Ryo Aizawa, Dai Suzuki, Masayuki Tsukasaki, Wataru Suzuki, Mutsuko Nakayama, Koutaro Maki, Matsuo Yamamoto, Kazuyoshi Baba, Ryutaro Kamijo
      • PLoS One 8(6) e68774, 2013.

2012

原著

  • Nephronectin expression is regulated by SMAD signaling in osteoblast-like MC3T3-E1 cells
    • Masayuki Tsukasaki, Atsushi Yamada, Kentaro Yoshimura, Agasa Miyazono, Matsuo Yamamoto, Masamichi Takami, Yoichi Miyamoto, Naoko Morimura, Ryutaro Kamijo
      • Biochemical and Biophysical Research Communications  425(2): 390-392, 2012. 
  • Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development
    • Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Tadahiro Iimura, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tetsuhiko Tachikawa, Kazuki Nakao, Matsuo Yamamoto, Akira Yamaguchi, Atsu Aiba, Ryutaro Kamijo
      • Mechanisms of Development 129(1-4): 38-50, 2012.

2011

原著

  • Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α.
    • Masayuki Tsukasaki, Atsushi Yamada, Dai Suzuki, Ryo Aizawa, Agasa Miyazono, Yoichi Miyamoto, Tetsuo Suzawa, Masamichi Takami, Kentaro Yoshimura, Naoko Morimura, Matsuo Yamamoto, Ryutaro Kamijo
      • Biochemical and Biophysical Research Communications 410(4): 766-770, 2011.